ID 109945
Title Transcription
カンセツ リウマチ ニ タイスル メトトレキセート チリョウチュウ ニ コウド ノ ハンケッキュウ ゲンショウ オ キタシ シボウ シタ 5レイ ノ ケントウ
Title Alternative
The clinical features of 5 cases that died of severe pancytopenia under treatment with low-dose MTX for rheumatoid arthritis
Author
Uemura, Munenori The Center of Medical Education, Tokushima Prefectural Central Hospital
Morita, Yutaka The Center of Medical Education, Tokushima Prefectural Central Hospital
Udaka, Kengo Department of Hematology, Tokushima Prefectural Central Hospital
Sekimoto, Etsuko Department of Hematology, Tokushima Prefectural Central Hospital
Shibata, Hironobu Department of Hematology, Tokushima Prefectural Central Hospital
Shigekiyo, Toshio Department of Hematology, Tokushima Prefectural Central Hospital
Ozaki, Shuji Department of Hematology, Tokushima Prefectural Central Hospital
Keywords
pancytopenia
low-dose MTX
the elderly
renal insufficiency
Content Type
Journal Article
Description
Background : Methotrexate (MTX) is placed as an anchor drug of treatment for rheumatoid arthritis (RA). However, many cases suffered from side effects of MTX such as interstitial pneumonia and hematological toxicity. We investigated 5 cases that died of severe pancytopenia under treatment with low-dose MTX for RA.
Methods : We reviewed the clinical features of 5 cases that developed severe pancytopenia and were transferred to Tokushima Prefectural Central Hospital under treatment with low-dose MTX for RA from 2011-2015.
Results : All the cases were women, and were under treatment with low-dose MTX. The periods of medication of MTX were not clear. All the cases had renal insufficiency, and had a severe infection induced by pancytopenia and some cases developed disseminated intravascular coagulation (DIC). At once we started intensive care, but all patients died in a short term.
Conclusions : Women, the elderly, and renal insufficiency can be risk factors of severe pancytopenia induced by MTX even if low dosage. We should carefully treat these patients with MTX.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
71
Issue
5-6
Start Page
155
End Page
158
Sort Key
155
Published Date
2015-12-25
FullText File
language
jpn
TextVersion
Publisher