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ID 109976
Title Alternative
食事中のリンが糖代謝および脂質代謝における効果
PHOSPHATE REGULATES GLUCOSE AND LIPID METABOLISM
Author
Abuduli, Maerjianghan Tokushima University
Kubo, Hitoshi Fukushima Medical University KAKEN Search Researchers
Ueda, Haruka Tokushima University
Keywords
Brown adipose tissue
dietary phosphate
energy metabolism
visceral fat
Content Type
Thesis or Dissertation
Description
Recent epidemiological and animal studies have suggested that excess intake of phosphate (Pi) is a risk factor for the progression of chronic kidney disease and its cardiovascular complications. However, little is known about the impact of dietary high Pi intake on the development of metabolic disorders such as obesity and type 2 diabetes. In this study, we investigated the effects of dietary Pi on glucose and lipid metabolism in healthy rats. Male 8-wk-old Sprague-Dawley rats were divided into three groups and given experimental diets containing varying amounts of Pi, i.e., 0.2 [low Pi (LP)], 0.6 [control Pi (CP)], and 1.2% [high Pi (HP)]. After 4 wk, the HP group showed lower visceral fat accumulation compared with other groups, accompanied by a low respiratory exchange ratio (V˙ CO2/V˙ O2) without alteration of locomotive activity. The HP group had lower levels of plasma insulin and nonesterified fatty acids. In addition, the HP group also showed suppressed expression of hepatic lipogenic genes, including sterol regulatory element-binding protein-1c, fatty acid synthase, and acetyl-CoA carboxylase, whereas there was no difference in hepatic fat oxidation among the groups. On the other hand, uncoupling protein (UCP) 1 and peroxisome proliferator-activated receptor-γ coactivator-1α(PGC-1α) expression were significantly increased in the brown adipose tissue (BAT) of the HP group. Our data demonstrated that a high-Pi diet can negatively regulate lipid synthesis in the liver and increase mRNA expression related to lipid oxidation and UCP1 in BAT, thereby preventing visceral fat accumulation. Thus, dietary Pi is a novel metabolic regulator.
Journal Title
American Journal of Physiology-Endocrinology and Metabolism
ISSN
01931849
15221555
NCID
AA00066467
AA12004897
Publisher
The American Physiological Society
Volume
310
Issue
7
Start Page
E526
End Page
E538
Published Date
2016-01-19
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201611301001.pdf
論文本文:LID201611301002.pdf
本論文は, 著者Maerjianghan Abuduliの学位論文として提出され, 学位審査・授与の対象となっている。
著者の名「瑪尓江汗」の正式な漢字については審査要旨のpdfをご参照ください。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2993号
Diploma Number
甲栄第238号
Granted Date
2016-09-29
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences
Advance Radiation Research, Education, and Management Center