ID 109999
Author
Sato, Youichi Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tajima, Atsushi Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School|Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University
Katsurayama, Motoki Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School
Nozawa, Shiari Department of Urology, St. Marianna University School of Medicine
Yoshiike, Miki Department of Urology, St. Marianna University School of Medicine
Koh, Eitetsue Department of Urology, Kanazawa University Graduate School of Medical Sciences
Kanaya, Jiro Department of Urology, Kanazawa University Graduate School of Medical Sciences
Namiki, Mikio Department of Urology, Kanazawa University Graduate School of Medical Sciences
Matsumiya, Kiyomi Department of Urology, Suita Tokushukai Hospital
Tsujimura, Akira Department of Urology, Graduate School of Medicine, Faculty of Medicine, Osaka University
Komatsu, Kiyoshi Department of Urology, Harasanshinkai Hospital
Itoh, Naoki Department of Urology, Sapporo Medical University
Eguchi, Jiro Department of Urology, Nagasaki University
Imoto, Issei Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yamauchi, Aiko Department of Pharmaceutical Information Science, Institute of Biomedical Sciences, Tokushima University Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Iwamoto, Teruaki Department of Urology, St. Marianna University School of Medicine|Center for Infertility and IVF, International University of Health and Welfare Hospital
Content Type
Journal Article
Description
In men, follicle-stimulating hormone (FSH) acts on the seminiferous tubules and enhances spermatogenesis. Recently, a candidate locus (rs2414095) for FSH levels was identified by a genome-wide association study (GWAS) in Chinese men. The rs2414095 SNP is found on the third intron of the cytochrome P450, family 19, subfamily A, peptide 1 (CYP19A1) gene encoding an aromatase. In the present study, we performed a replication study in 1687 Japanese men (901 from cohort 1 and 786 from cohort 2) to assess whether this single nucleotide polymorphism (SNP) is associated with circulating FSH levels. Furthermore, we investigated whether the rs2414095 SNP is correlated with semen quality traits in 2015 Japanese men (1224 from cohort 1 and 791 from cohort 2). The rs2414095 SNP was significantly associated with circulating FSH levels (βSTD = 0.15, P = 9.7 × 10-5), sperm concentration (βSTD = 0.073, P = 0.032), and total sperm number (TSN) (βSTD = 0.074, P = 0.027) in a combined analysis of the two Japanese male cohorts. We successfully replicated, in Japanese men, the results of the previous GWAS for the rs2414095 SNP in Chinese men, and found that the rs2414095 SNP was related with sperm production.
Journal Title
Journal of Human Genetics
ISSN
14345161
NCID
AA11206160
Volume
61
Issue
11
Start Page
911
End Page
915
Sort Key
911
Published Date
2016-11
Remark
Running title : Candidate polymorphism associated with FSH levels

© 2016 The Japan Society of Human Genetics

論文本文 : LID201701242001.pdf
Table 1 : LID201701242002.pdf
Table 2 : LID201701242003.pdf
Table 3 : LID201701242004.pdf
EDB ID
Published Source
Journal of Human Genetics (2016) Vol.61 No.11 p.911-915
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Pharmaceutical Sciences
Medical Sciences