ID 110023
Title Transcription
ゲノム エピゲノム イジョウ オ シヒョウ トスル ガン ト イデン シッカン カンレン イデンシ タンサク ケンキュウ
Title Alternative
Identification of human cancer-associated genes using comparative genomic and epigenomic analyses
Author
Imoto, Issei Department of Human Genetics, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Cancer
genome
epigenome
copy-number analysis
Content Type
Journal Article
Description
Genetic abnormalities/variations contribute to the most of human diseases including cancer and congenital disorders. Advances in tools for human genome analysis, such as genomic arrays and next-generation sequences, based on the information of human genome sequences provided a great opportunity to identify novel causative genes and disease-associated genes through whole exploration of disease-specific abnormalities in the sequence and copy-number levels. Novel target genes for cancer diagnosis and therapy could be identified through combined structural and functional approach for cancer genome using whole genome and epigenome scanning by array and sequencer as well as functional and expression analyses of candidate genes, resulting in the development of novel diagnostic and therapeutic methods useful for the ‘ personalized medicine’ .
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
68
Issue
5-6
Start Page
211
End Page
216
Sort Key
211
Published Date
2012-12-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences