ID 110203
Title Transcription
ココマデ ヨクナル コドモ ノ ジンエン ネフローゼ
Title Alternative
Treatment of IgA nephropathy and nephrotic syndrome in children
Author
Kondo, Shuji Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School
Keywords
IgA nephropathy
nephritic syndrome
prednisolone
ciclosporin
Content Type
Journal Article
Description
Recent progress and success for the treatment of IgA nephropathy and frequently relapsing and steroid-dependent nephrotic syndrome have been observed. Treatment with prednisolone,
immunosuppressive agents, anti-platelet drugs, and anti-coagulation early in the course of disease suppresses urinary protein excretion and reduces immunologic renal injury, and thereby prevents progression to renal failure in children with severe IgA nephropathy. This suggests that urinary screening of school children is important to detect children with severe IgA nephropathy. On the other hand, treatment with ciclosporin, calcineurin inhibitor, in children with steroid-dependent nephrotic syndrome induces complete remission and reduces frequency of recurrence. In addition, administration of ciclosporin reduces steroid-induced side effects including osteoporosis and short stature. In conclusion, these progresses of treatments have improved outcome and quality of lives of children with severe IgA nephropathy or steroid-dependent nephrotic syndrome.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
63
Issue
5-6
Start Page
201
End Page
203
Sort Key
201
Published Date
2007-12-20
EDB ID
FullText File
language
jpn
TextVersion
Publisher