ID 110207
Title Transcription
UVA ユウドウ ヒフ ヒカリロウカ ニオケル シシツ カサンカブツ ノ ヤクワリ ト コウサンカ ブッシツ セッシュ ノ エイキョウ
Title Alternative
Effect of peroxidized lipids on UVA-induced photoaging in mouse skin and its inhibition by dietary antioxidants
Author
Minami, Yuko Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima
Kawabata, Kyuichi Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima
Yokoyama, Kanako Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima
Bando, Noriko Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School
Kawai, Yoshichika Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Terao, Junji Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
UVA
cholesterol peroxidative products
matrix metalloproteinase
β-carotene
Content Type
Journal Article
Description
Role of ultraviolet A(UVA)on oxidative damage has attracted much attention in relation to skin photoaging process. In this study, we investigated effect of cholesterol hydroperoxides(Chol- OOHs), stable products of reactive oxygen species(ROS)-induced lipid peroxidation, on matrix metalloproteinase(MMP)activation responsible for wrinkle formation in hairless mouse skin and then estimated the inhibition of UVA-induced MMP activation by dietary β-carotene. Hairless mice were exposed to UVA irradiation for 8 weeks. Chol-OOHs content in the skin was found to increase significantly by the exposure of UVA. In addition, the activity of MMP-9 and its protein expression were elevated with wrinkle formation. This activation was also induced by intracutaneous injection of Chol-OOHs. Interestingly, dietary β-carotene(500 mg/kg diet) and α-tocopherol (100 mg/kg diet)suppressed the accumulation of Chol-OOH as well as MMP activation. These results suggest that Chol-OOHs formed by the exposure of UVA to skin contribute to the activation of MMPs resulting in skin photoaging. Dietary antioxidants may prevent skin photoaging through, at least partly, the suppression of MMP activation due to UVA-induced lipid peroxidation.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
63
Issue
5-6
Start Page
219
End Page
223
Sort Key
219
Published Date
2007-12-20
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences