ID 110223
Title Transcription
シンコウセイ ドウミャク コウカセイ ビョウヘン ニ タイシ ショウサイナ ビョウリ ソシキガクテキ ケントウ オ オコナイ エタ コウLp(a) ケッショウ ガッペイ 2ガタ トウニョウビョウ ノ 1レイ
Title Alternative
A case of type 2 diabetes mellitus showing elevated plasma lipoprotein(a) levels with various atherosclerotic lesions
Author
Tsuruo, Miho Terasawa Hospital
Akaike, Masashi Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Terasawa, Toshihide Terasawa Hospital
Mihara, Masatomo Terasawa Hospital|Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Azuma, Hiroyuki Department of Internal Medicine, Anan Kyoei Hospital
Matsumoto, Toshio Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
type 2 diabetes
lipoprotein(a)
apolipoprotein(a)
atherosclerosis
aspirin
Content Type
Journal Article
Description
We report a case of type 2 diabetes mellitus showing elevated plasma lipoprotein(a)[Lp(a)]levels with various atherosclerotic lesions. A 54-year-old woman diagnosed as having type 2 diabeteswas treated with oral antidiabetic drugs. She had various atherosclerotic lesions, includingcerebral infarction, occlusion of the middle carotid artery and myocardial infarction, along withdiabetes mellitus, hyperlipemia and hypertension and additionally showed a high level of serum Lp(a). A high plasma level of Lp(a)is considered to be an independent risk factor for atherosclerosis,and it is associated with the development of cerebral infarction, occlusion of the middlecarotid artery and coronary atherosclerosis. Plasma Lp(a)level is predominantly determined bygenetic factors and is not affected by diet or drugs. Aspirin treatment(100 mg/day)lowered theplasma level of Lp(a)by 60%. Pathological findings of the vascular lesions showed that apolipoprotein(a)[apo(a)], a major apoprotein component of Lp(a), was deposited in the tunica media ofthe radial artery with rare atherosclerotic lesions and in the inner rim of the fibrous capsular regionwithin the plaque with a large lipid core of the carotid artery. This suggests that Lp(a)stimulatesthe transformation of vascular smooth muscle cells in the tunica media in the early stage of atherosclerosisand that it is associated with fragility of the atherosclerotic lesion in the progressive stage.Hence, plasma Lp(a)levels should be measured for diabetic patients with various atheroscleroticlesions, and aspirin may need to be given to those who have elevated plasma Lp(a)levels in orderto prevent the development of atherosclerotic complications.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
64
Issue
1-2
Start Page
41
End Page
46
Sort Key
41
Published Date
2008-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
Institute of Advanced Medical Sciences