ID 110246
Title Transcription
キソ カラ リンショウ エ MR オ モチイタ タイシャ キノウ カシカ ノ サイゼンセン
Title Alternative
Development of the visualization technique of metabolites functions using magnetic resonance imaging and spectroscopy
Author
Kubo, Hitoshi Department of Medical Imaging, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Harada, Masahumi Department of Medical Imaging, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Abe, Takamasa Biotools Group, Oxford Instruments, Co., Ltd
Nishitani, Hiromu Department of Radiology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
magnetic resonance imaging and spectroscopy
metabolites function
molecular imaging
Content Type
Journal Article
Description
Medical imaging plays an essential role in the clinical settings in Japan.Especially, magnetic resonance imaging(MRI)that measure1H behavior is widely acceptedas indispensable apparatus for daily clinical activities and researches as both morphological andfunctional imaging.Recently, measurement techniques of other nuclides such as13C,18F and31P are being developedand trying to be applied in in vivo. Of them,13C is the most suitable nuclide to observemetabolites functions of cells or organs and has possibilities to visualize these functions in in vivothough the sensitivity is quite low in comparison with1H. Development of the technique to increasesensitivity is needed to apply in clinical settings and some methods are evaluated now.Using13C enriched chemicals administrate to human is tried to observe metabolites function in invivo with MR Spectroscopy. Hyperpolarized technique that induces significantly increasing signalsof13C is developed as next generation method and exploited in in vivo imaging of animals tovisualize metabolites functions.We should develop and practice these new techniques to visualize metabolites functions in invivo and it may be beyond the conventional diagnostic imaging techniques. It may induce newdiagnostic imaging technique using physiological and biochemical approach in clinical settings.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
64
Issue
5-6
Start Page
170
End Page
174
Sort Key
170
Published Date
2008-12-20
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences