ID 110257
Title Transcription
ABO ケツエキガタ ノ コウゲン オヨビ イデンシ ノ カイセキ ト リンショウテキ オウヨウ
Title Alternative
Detection of ABO blood group antigens and genetic analysis of ABO blood group and their application for clinical studies
Author
Hosoi, Eiji Department of Cells and Immunity Analytics, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
ABO blood group system
cisAB allele
transfusion medicine
flow cytometry
PCR amplification of specific alleles(PASA)
Content Type
Journal Article
Description
The ABO blood group system is the most important blood group system among the 29 International Society of Blood Transfusion(ISBT)-recognized systems, consisting of four antigens (A, B, O, and AB). These antigens are known as oligosaccharide antigens, and widely expressed on the membrane of red cell and tissue cells as well as, in the saliva and body fluid. The ABO blood group system was discovered by the Austrian scientist Karl Landsteiner, who found three different blood types(A, B, and O)in 1900 from serological differences in blood. In 1902, DeCasterllo and Stürli discovered the fourth type, AB. The phenomenon of these serological differences was called the Landsteiner Law, and is still used to detect ABO blood group antigens in clinical laboratories. In 1924, Felix Bernstein predicted that the mechanism of inheritance involved three alleles at the ABO locus from extensive family studies. Furthermore, the structure and biochemical characteristics of the ABO antigens were elucidated by many investigators. In recent years, the ABO blood group at chromosome locus 9 has been determined, the gene cloned and the structures determined by Yamamoto et al . This has made it possible to genetically analyses of ABO blood group antigens using molecular biology techniques. Clinically, blood group antigens are important. In particular, the ABO blood group antigens are one of the most important issues in transfusion medicine, evaluation of the adaptability of donor blood cells with bone marrow transplantations, and survival confirmation of hemocytes. This article reviews the serology, biochemistry, biosynthesis and genetic characteristics of ABO antigens, and the analysis of ABO blood group using flow cytometry and polymerase chain reaction(PCR)amplification of specific alleles(PASA)-method and their application for clinical studies.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
64
Issue
5-6
Start Page
216
End Page
224
Sort Key
216
Published Date
2008-12-20
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences