ID 110282
Title Transcription
microRNA デ カガク ホウシャセン リョウホウ ノ コウカ オ ヨソクスル
Title Alternative
MicroRNA expression predicts pathological response to chemoradiotherapy in rectal cancer
Author
Nishioka, Masanori Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School
Shimada, Mitsuo Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Utsunomiya, Toru Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Kurita, Nobuhiro Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Iwata, Takashi Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Morimoto, Shinya Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School
Yoshikawa, Kozo Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Higashijima, Jun Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
micro RNA
rectal cancer
chemoradiotherapy
S-1
pathological response
Content Type
Journal Article
Description
While global microRNA(miRNA)expression patterns of many embryologic, physiologic, and oncogenic processes have been described, description of the role of miRNAs for preoperative chemoradiotherapy(CRT)in rectal cancer is lacking. Our purpose of this study was to define the expression pattern of miRNAs for prediction of response to chemoradiotherapy in rectal cancer. Rectal cancer patients(n=22)who underwent preoperative CRT(40Gy radiotherapy combined with S-1)were studied. S-1 is a novel oral fluoropyrimidine inhibitory for dihydropyrimidine dehydrogenase and has potent radiosensitizing property. RNA harvested from biopsy specimens of rectal cancer before preoperative CRT was hybridized to miRNA microarrays(821genes). Response to CRT was determined by histopathologic examination(Japanese Society for Cancer of the Colon and Rectum)of surgically resected specimens and RECIST. Groups were classified as responders( grade 2 or 3, CR or PR)or nonresponders(grade 0 or 1, SD or PD), respectively. Response to CRT determined by histopathologic examination of surgically resected specimens and RECIST were as follows : responders(grade 2 or 3, n=15),(PR, n=14), nonresponders(grade 0 or 1, n=7)(, SD, n=8). Response rate was68%(grade 2 or 3)and 63%(PR). Two miRNAs(miR- 142, 223)with increased expression were identified that correctly differentiated responders from nonresponders of CRT by histopathologic examination. One overexpressed(miR-223)and 4 underexpressed miRNAs(miR-17, 20, 92, 106)differentiated responders from nonresponders of CRT by RECIST. Rectal cancer may have a distinct miRNA expression to predict pathological response to preoperative chemoradiotherapy.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
65
Issue
3-4
Start Page
88
End Page
92
Sort Key
88
Published Date
2009-08-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
Liberal Arts and Sciences
University Hospital