右手指に急速に壊疽性病変を生じた抗リン脂質抗体症候群の1例

A ７７‐year‐old female was referred to our clinic in July ４，２００８ with a week history of rapidly progressive necrotic skin lesions on her right fingers. She had been under treatments of mixed connective tissue disease（MCTD）since １９９１. Laboratory findings revealed prolongation of activated partial thromboplastin time（aPTT）and the presence of lupus anticoagulant. We diagnosed this case as MCTD followed by antiphospholipid syndrome（APS）. After the treatment of Prostaglangin E１and Sarpogrelate hydrochloride, low dose of oral aspirin was started. Necrotic lesions of her fingers improved gradually, and she was discharged in September２１. APS should be considered when we see rapidly progressive necrotic skin lesions on patients with collagen deseases.