ID 110298
Title Transcription
チョウカン トランス ポーター オ ブンシ ヒョウテキ トシタ ジンシッカン チリョウホウ ノ カクリツ オ メザシテ
Title Alternative
The establishment of therapy targeting the intestinal transporter genes for chronic kidney disease
Author
Kikuchi, Hiroko Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Yamamoto, Hironori Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Tanaka, Sarasa Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Nakahashi, Otoki Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Kuwahara, Shoji Department of Molecular Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Nii, Yoshitaka Food Technology Division, Tokushima Prefecture Industrial Technology Center
Miyamoto, Ken-ichi Department of Molecular Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Taketani, Yutaka Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Takeda, Eiji Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
CKD
intestinal transporter gene
DNA microarray
Content Type
Journal Article
Description
The understanding of intestinal function in chronic kidney disease(CKD)has been important elements in the clinical management of CKD with dietary and drug therapy. Numerous studies have indicated that CKD patients or model rats have enzymatic abnormalities and impairments of absorptive function in the small intestine. However, it has been still unclear how different of the intestinal function in CKD. In this study, we demonstrated the microarray analysis of global gene expression in intestine of adenine-induced CKD rat. DNA microarray analysis using Affymextrix rat gene chip revealed that CKD caused great changes in gene expression in the rat duodenum : about400genes exhibited more than a two-fold change in expression level. Gene ontology analysis showed that a global regulation of genes by CKD involved in iron ion binding, alcoholic, organic acid and lipid metabolism. Furthermore, we found markedly changes of a number of intestinal transporters gene expression. These results suggest that CKD may alter some nutrient metabolism in the small intestine by modifying the expression of specific genes. The intestinal transcriptome database of CKD might be useful to develop the novel drugs or functional foods targeting several intestinal genes including transporters for the management of CKD.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
65
Issue
5-6
Start Page
173
End Page
176
Sort Key
173
Published Date
2009-12-20
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences