ID 110321
Title Transcription
ピオグリタゾン トウヨ ニヨル フクブ ダイドウミャクリュウ ニオケル コウドウミャク コウカ サヨウ
Title Alternative
Prelimenary evaluation of preoperative Pioglitazone administration on abdominal aortic aneurysm
Author
Motoki, Tatsuo Department of Cardiovascular Surgery, the University of Tokushima Graduate School
Kurobe, Hirotsugu Department of Cardiovascular Surgery, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hirata, Yoichiro Department of Cardiovascular Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School
Terahashi, Atsuko Department of Cardiovascular Surgery, the University of Tokushima Graduate School
Sugano, Mikio Department of Cardiovascular Surgery, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yoshida, Homare Department of Cardiovascular Surgery, the University of Tokushima Graduate School
Kanbara, Tamotsu Department of Cardiovascular Surgery, the University of Tokushima Graduate School KAKEN Search Researchers
Kitaichi, Takashi Department of Cardiovascular Surgery, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sata, Masataka Department of Cardiovascular Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kitagawa, Tetsuya Department of Cardiovascular Surgery, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
inflammatory cytokines
fat tissues
aneurismal wall
insulin-resistance
Content Type
Journal Article
Description
Accumulating evidence suggests that inflammatory cytokines secreted from visceral fat tissues potentially promote atherosclerosis progression. Recent reports suggested that pioglitazone, which is an anti-diabetes drug, reduces expression of tumor necrosis factor(TNF)‐α and ameliorates insulin-resistance in diabetic mice. Pioglitazone was also reported to suppress progression of coronary atherosclerosis. The objective of this study is to assess the effect of pioglitazone on inflammatory changes in abdominal aortic aneurysms(AAAs). This study protocol was approved by the medical ethics committee in Tokushima University Hospital. Patients with AAA were randomized into two groups. One was with pioglitazone(Group P). The other was without pioglitazone(Group C). Biopsy specimens were obtained from the abdominal subcutaneous fat, the greater omentum, the retroperitoneal periaortic fat and the aneurysmal wall. Immunohistochemistry of CD 68in those specimens was performed. The number of macrophages in Group P was lower than that in Group C. Expressions of inflammatory cytokines in those specimens were evaluated by real-time quantitative reverse transcription-polymerase chain reaction analysis. Expression of inflammatory cytokines in Group P were reduced, when compaird with those in Group C.
Our data may suggest that pioglitazone reduce inflammatory changes in human aortic aneurysm.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
66
Issue
3-4
Start Page
91
End Page
94
Sort Key
91
Published Date
2010-08-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital