ID 110336
Title Transcription
センタクテキ スプライシング ハンノウ ニヨル イデンシ ハツゲン セイギョ
Title Alternative
Regulation of gene expression by alternative splicing
Author
Kurokawa, Ken Department of Stress Science, Institute of Health Biosciences, the University of Tokushima Graduate School
Tanahashi, Toshihito Department of Stress Science, Institute of Health Biosciences, the University of Tokushima Graduate School
Masuda, Kiyoshi Department of Stress Science, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Kuwano, Yuki Department of Stress Science, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Rokutan, Kazuhito Department of Stress Science, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
alternative splicing
SRSF
PTC
NMD
Content Type
Journal Article
Description
The human genome sequence has been decoded, and the more complicated regulation of gene function is revealed in the post-genome era. In the various mechanisms of epigenome, RNA dramatically controls gene expression through the various post-transcriptional processing including transcription, splicing, cap addition, polyadenylation, nuclear export, translation. Especially, the alternative splicing is involved in all of those post-transcriptional regulations, as well as splicing of pre-mRNA. However, there were few reports, how the alternative splicing contributes to the regulations of cellular functions because of its difficulty of the analysis. This review discusses the molecular mechanism of alternative splicing and its regulator ; Serine/arginine-rich splicing factor (SRSF). We also discuss how the SRSF genes sustain their own proper expressions and functions.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
66
Issue
5-6
Start Page
157
End Page
162
Sort Key
157
Published Date
2010-12-20
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences