ID 110346
Title Transcription
ショウカキガン ニオケル HIF-1 ノ リンショウテキ イギ ト チリョウ エノ オウヨウ
Title Alternative
Clinical significance and therapeutic implication of Hypoxia Inducible Factor-1(HIF-1) expression in gastrointestinal cancer
Author
Utsunomiya, Tohru Department of Digestive Surgery and Transplantation, Tokushima University Hospital|Cancer Management Center, Tokushima University Hospital
Shimada, Mitsuo Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Imura, Satoru Department of Digestive Surgery and Transplantation, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Morine, Yuji Department of Digestive Surgery and Transplantation, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ikemoto, Tetsuya Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hanaoka, Jhun Department of Digestive Surgery and Transplantation, Tokushima University Hospital
Mori, Hiroki Department of Digestive Surgery and Transplantation, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kanamoto, Mami Department of Digestive Surgery and Transplantation, Tokushima University Hospital KAKEN Search Researchers
Iwahashi, Shuichi Department of Digestive Surgery and Transplantation, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Saito, Yu Department of Digestive Surgery and Transplantation, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yamada, Shinichiro Department of Digestive Surgery and Transplantation, Tokushima University Hospital
Asanoma, Michihito Department of Digestive Surgery and Transplantation, Tokushima University Hospital
Miyake, Hidenori Department of Digestive Surgery and Transplantation, Tokushima University Hospital
Keywords
hypoxia inducible factor‐1
histone deacetylase
epigenetics
cancer stem cell
epithelial-mesenchymal transition
Content Type
Journal Article
Description
Hypoxia inducible factor‐1α(HIF‐1α)and histone deacetylase(HDAC)expressions in gastrointestinal cancer, especially intrahepatic cholangiocarcinoma and pancreas cancer, significantly reflect on the malignant potential of these cancers, and are significantly associated with patient’s prognosis. It has also been shown that HIF‐1α is deacetylated and stabilized by nucleosome remodeling and histone deacetylation (NuRD) complex, consisting of HDAC and metastasis-associated gene‐1(MTA1), leading to angiogenesis. More recently, it has been reported that HIF‐1α induces tumorigenesis and ultimately cancer stemness through epithelial-mesenchymal transition (EMT). Therefore, HIF‐1α may be one of the master molecules of cancer progression, and it is expected that novel therapeutic strategies will be devised by controlling the signaling pathway of HIF‐1α in hypoxic condition of gastrointestinal cancer.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
67
Issue
1-2
Start Page
15
End Page
20
Sort Key
15
Published Date
2011-04-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital