ID 110350
Title Transcription
シュウマツキ ガン ショウレイ ニオケル コウカルシウム ケッショウ ノ ケントウ
Title Alternative
Hypercalcemia in patients with end-stage cancer
Author
Miki, Hitoshi Division of Palliative Care, Kondo-Naika Hospital
Ueda, Yuriko Division of Palliative Care, Kondo-Naika Hospital
Arase, Tomoko Division of Palliative Care, Kondo-Naika Hospital
Kondo, Akira Division of General Medicine, Kondo-Naika Hospital
Keywords
hypercalcemia
cancer
end-stage
palliative care
bisphosphonates
Content Type
Journal Article
Description
Hypercalcemia develops in patients with advanced cancer and severely deteriorates their quality of life. This study aimed to evaluate the influence of hypercalcemia on the clinical course of patients with end-stage cancer. This retrospective study included data on 253 patients who had cancer and died in the palliative care unit at Kondo-Naika Hospital in 2008 and 2009. Of these patients, 16(6.3%) developed hypercalcemia during hospitalization before death. These 16 patients included5patients with lung cancer ;4 with esophageal cancer ;2 with pancreatic cancer ; and1patient each with liver cancer, breast cancer, gall bladder cancer, renal cancer, or gastric cancer. The incidence of esophageal cancer in the patients with hypercalcemia was significantly higher than that in the patients who did not have hypercalcemia(p<0.01). Of the 16 patients with hypercalcemia,10had bone metastasis, whereas the other6patients had hypercalcemia even without bone metastasis. The main symptom of hypercalcemia was drowsiness in7patients, delirium in6patients, and general fatigue in 3patients. Fifteen patients were treated using bisphosphonates. After the hypercalcemia was detected, the 16patients survived for only a short time, with a mean survival time of 16.9 days. In particular, the mean survival time of 7 patients who did not respond to treatment for hypercalcemia was only 6.0days, and1patient with a calcium level of 19.1 mg/dl died the day after zoledronic acid hydrate therapy was initiated. Thus, hypercalcemia in patients with end-stage cancer seems to indicate extremely critical conditions with the worst prognosis.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
67
Issue
1-2
Start Page
35
End Page
38
Sort Key
35
Published Date
2011-04-25
FullText File
language
jpn
TextVersion
Publisher