ID 110365
Title Transcription
Erlotinib デ induction therapy オ オコナッタ IIIAキ ヒショウサイボウ ハイガン ノ 1シュジュツレイ
Title Alternative
A surgical case of stage IIIA non-small cell lung cancer with EGFR-TKI as induction therapy
Author
Sakamoto, Shinichi Center for Post-graduate Medical Education Hospital, Tokushima University Hospital
Kajiura, Koichiro Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School KAKEN Search Researchers
Takizawa, Hiromitsu Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakagawa, Yasushi Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School KAKEN Search Researchers
Ikeda, Mayumi Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School
Furukawa, Takako Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School
Morimoto, Masami Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Nishino, Takeshi Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Goto, Masakazu Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakagawa, Misako Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School KAKEN Search Researchers
Yamamoto, Yota Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School KAKEN Search Researchers
Furukita, Yoshihito Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School
Takechi, Hirokazu Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yoshida, Mitsuteru Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kawakami, Yukikiyo Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tadokoro, Yukiko Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School KAKEN Search Researchers
Sakiyama, Shoji Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School KAKEN Search Researchers
Kondo, Kazuya Department of Oncological Medical Services, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Bando, Yoshimi Department of Molecular Environmental pathology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Okazaki, Hiroyasu Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School
Goto, Hisatsugu Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nishioka, Yasuhiko Department of Respiratory Medicine and Rheumatology, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tangoku, Akira Department of Thoracic Endocrine surgery and Oncology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
NSCLC
EGFR-TKI
EGFR-mutation
induction-therapy
adjuvant-therapy
Content Type
Journal Article
Description
[Background ]Erlotinib, epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI), is effective for advanced and metastatic non-small cell lung cancer(NSCLC)with EGFR mutation. However, the report of Erlotinib as induction therapy is rare. We report a surgical case of NSCLC with Erlotinib as induction therapy. [Case ]A41-years-old man, diagnosed left lung adenocarcinoma with EGFR mutation(exon19deletion), was referred to our hospital. CT showed that the tumor was 35mm in S8 of the left lung and #7 lymphnode was swelling markedly(cT2aN2M0 stage ⅢA). He took Erlotinib(150mg/day)for12weeks at first because of EGFR mutation positive. The evaluation of Erlotinib was partial response in RESIST. He could take radical operation as lower lobe and lingual segment resection, because CT showed bulky #7got smaller significantly. There was no postoperative complication. The pathological finding was adenocarcinoma(papillary& acinartype), PL0, v(+), ly(+), br(-), pa(-), pv(-), Ef :1b,(ypT1aN2M0stage ⅢA). He has taken adjuvant therapy(Erlotinib150mg/day)for28weeks. There is no recurrence six months after operation. [Conclusion ]It is possible that Erlotinib as induction-therapy is very effective in patients with EGFR mutation like this case ; however there is no evidence of EGFR-TKI as induction therapy. It is necessary to validate the effectiveness of Erlotinib as induction therapy.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
68
Issue
5-6
Start Page
251
End Page
256
Sort Key
251
Published Date
2012-12-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital