ID 110377
Title Transcription
2ガタ トウニョウビョウ カンジャ ニオケル ケットウ シヒョウ ト ゲンエン ガ モタラス ケツアツ テイカ トノ レンカン
Title Alternative
Correlation between glycemic index and sodium restriction-induced blood pressure reduction in hospitalized patients with type2diabetes mellitus
Author
Morimoto, Kana Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School
Aihara, Ken-ichi Department of Community Medicine for Diabetes and Metabolic Disorders, Institute of Biomedical Sciences, Tokushima University Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yoshida, Sumiko Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kurahashi, Kiyoe Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School Tokushima University Educator and Researcher Directory
Tamaki, Motoyuki Diabetes Therapeutics and Research Center, Tokushima University KAKEN Search Researchers
Kondo, Takeshi Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School KAKEN Search Researchers
Kuroda, Akio Diabetes Therapeutics and Research Center, Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Endo, Itsuro Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Matsuhisa, Munehide Diabetes Therapeutics and Research Center, Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Abe, Masahiro Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
type 2 diabetes mellitus(T2DM)
odium restriction-induced blood pressure reduction
Content Type
Journal Article
Description
Background : The majority of patients with type2diabetes mellitus(T2DM)have hypertension, leading to serious cardiovascular events, including acute myocardial infarction, heart failure and stroke. Therefore, blood pressure(BP)control is a critical issue in patients with T2DM. Although sodium restriction is known to reduce BP, it is unclear what factors are associated with sodium restriction-induced BP reduction in T2DM patients.
Subjects and Methods : A retrospective analysis was performed in hospitalized patients with T2DM(66males and61females, mean age :58.1±14.2years, mean HbA1c :9.5±2.0%). They received diet therapy including sodium restriction as NaCl of5to8g/day during admission. The relationship between changes in systolic BP(SBP)during admission and clinical parameters at the time of admission was statistically analyzed.
Results : Mean SBP in the sodium-restricted patients was significantly reduced during admission( from 130.2±16.1 to 122.7±13.9 mmHg, p<0.01). Multiple regression analysis showed that serum creatinine levels and presence of hypertension were inversely associated with and that initial SBP value was positively associated with the change in SBP. On the other hand, no glycemic parameters, including fasting plasma glucose levels, HbA1c, M values calculated from daily blood glucose profile, duration of T2DM and duration of hospitalization, were associated with the change in SBP.
Conclusion : Sodium restriction-induced BP reduction in T2DM patients was associated with presence of hypertension, serum creatinine levels and initial SBP values. Sodium restriction is a useful treatment for T2DM patients regardless of their glycemic condition.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
72
Issue
1-2
Start Page
31
End Page
36
Sort Key
31
Published Date
2016-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital
Institute of Advanced Medical Sciences