ID 110415
Title Transcription
シュウジュツキ ノ ケッカン キノウ ホゴ センリャク
Title Alternative
Protective effects of anesthetics and perioperative managements on vascular function
Author
Kawahito, Shinji Department of Community Medicine and Human Resource Development, Tokushima University Graduate School, Institute of Biomedical Sciences Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Soga, Tomohiro Department of Community Medicine and Human Resource Development, Tokushima University Graduate School, Institute of Biomedical Sciences Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yagi, Shusuke Department of Community Medicine and Human Resource Development, Tokushima University Graduate School, Institute of Biomedical Sciences Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Matsushita, Shingo Department of Community Medicine and Human Resource Development, Tokushima University Graduate School, Institute of Biomedical Sciences KAKEN Search Researchers
Tani, Hiroe Department of Community Medicine and Human Resource Development, Tokushima University Graduate School, Institute of Biomedical Sciences Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Masuya, Sachiko Department of Community Medicine and Human Resource Development, Tokushima University Graduate School, Institute of Biomedical Sciences Tokushima University Educator and Researcher Directory
Keywords
Vascular function
Anesthetics
KATP channel
Oxidative stress
Intensive insulin therapy
Content Type
Journal Article
Description
Potassium channels play an essential role in the membrane potential of arterial smooth muscle, and also in regulating contractile tone. Especially, in vascular smooth muscle, the opening of adenosine triphosphate(ATP)-sensitive potassium(KATP)channels leads to membrane hyperpolarization, resulting in muscle relaxation and vasodilation. This activation also plays a role in tissues during pathophysiologic events such as ischemia, hypoxia, and vasodilatory shock. In this review, we will describe the physiological and pathophysiological roles of vascular smooth muscle KATP channels in relation to the effects of anesthetics and perioperative managements. Although accumulated evidence suggests that many anesthetics and perioperative managements(especially, diabetes and hyperglycemia)modify the above function of K+ channels as a metabolic sensor. Use of effective volatile anesthetics and the strict glycemic control may contribute to protect perioperative vascular function.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
73
Issue
1-2
Start Page
47
End Page
58
Sort Key
47
Published Date
2017-04-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences