ID 110426
Title Transcription
ゲンパツセイ アルドステロンショウ ノ シンダン ニ ユウヨウナ リンショウ ショケン ノ ケントウ
Title Alternative
Clinical parameters for diagnosis of primary aldosteronism
Author
Murakami, Takahiro The post-graduate Education Center,Tokushima University Hospital
Yagi, Shusuke Department of Cardiovascular Medicine ,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hara, Tomoya Department of Cardiovascular Medicine ,Tokushima University Hospital
Ise, Takayuki Department of Cardiovascular Medicine ,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kusunose, Kenya Department of Cardiovascular Medicine ,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Matsuura, Tomomi Department of Cardiovascular Medicine ,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tobiume, Takeshi Department of Cardiovascular Medicine ,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yamaguchi, Koji Department of Cardiovascular Medicine ,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yamada, Hirotsugu Department of Cardiovascular Medicine ,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Soegi, Takeshi Department of Cardiovascular Medicine ,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Wakatsuki, Tetsuzo Department of Cardiovascular Medicine ,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Shimabukuro, Mitsuo Department of Cardiovascular Medicine ,Tokushima University Hospital
Akaike, Masashi Department of Cardiovascular Medicine ,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sata, Masataka Department of Cardiovascular Medicine ,Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Shunto, Joji Shunto Gastrointestinal Clinic
Keywords
Primary aldosteronism
PAC/PRA
low serum potassium
Content Type
Journal Article
Description
Primary aldosteronism(PA)is known as a secondary hypertension. Hypertensive patients are screened by the plasma aldosterone concentration(PAC)/plasma renin activity(PRA)ratio as a case-detection test for PA. However, clinical parameters for screening patients with primary aldosteronism who need adrenalectomy have not been fully elucidated. We report a case of PA who received endoscopic adrenalectomy and evaluated the clinical parameters for screening patients with primary aldosteronism who need adrenalectomy, retrospectively. We evaluated43patients with PAC/PRA>200as a screening test for PA. Thirty-three(77%) patients were diagnoses as PA after confirmation test. In18patients who received adrenal vein sampling, 10 patients were diagnoses as unilateral adrenal adenoma. We compared clinical parameters between PA and non-PA. The level of PAC was lower in patients with PA compared to that in patients with non-PA. There were no significant change in the level of PAC, PAC/PRA, serum potassium, and blood pressure. PAC and PAC/PRA were higher and serum potassium was lower in patients who received adrenalectomy compared to those in patients without adrenalectomy. ROC curve showed that PAC>200 pg/mL and serum potassium <3.5mEq/L were useful parameters to predict diagnosis of PA who need adrenalectomy. In conclusion, PA patients with PAC>200pg/mL and serum potassium <3.5mEq/L should be considered as candidates for adrenorectomy.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
73
Issue
1-2
Start Page
113
End Page
116
Sort Key
113
Published Date
2017-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences
University Hospital