ID 110431
Title Transcription
ハイガン カンジャ ケッセイチュウ ニオケル ガン ヨクセイ イデンシ サンブツ pRB ニタイスル コウタイ ノ ケンシュツ
Title Alternative
Detection of anti-pRB antibodies in sera of lung cancer patients
Author
Yamamoto, Yuiko Department of Clinical Pharmacology, Faculty of Pharmaceutical Science, The University of Tokushima|Third Department of Internal Medicine, The University of Tokushima School of Medicine
Shimizu, Eiji Third Department of Internal Medicine, The University of Tottori School of Medicine
Yokota, Masayuki Department of Clinical Pharmacology, Faculty of Pharmaceutical Science, The University of Tokushima
Sone, Saburo Third Department of Internal Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
tumor suppressor gene
pRB
serum
autoantibody
lung cancer
Content Type
Journal Article
Description
Recently, serum antibodies against the oncogene and tumor suppressor gene products have been studied in patients with various types of cancer. Antibody against p53 tumor suppressor gene product among these antibodies was suggested to be useful for early diagnosis and evaluation of prognosis of patients with some types of cancer. In this article,we review clinical significance of antibodies against product of retinoblastoma gene (pRB),one of representative tumor suppressor genes. We also describe methods of detection of antibodies in sera from patients with lung cancer by immunoblotting assays using glutathione-S-transferase (GST)-RB fusion proteins.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
56
Issue
1
Start Page
1
End Page
12
Sort Key
1
Published Date
2000-02-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences