ID 110500
Title Transcription
トウニョウビョウセイ ニューロパチー ニオケル ジクサク イオン チャンネル キノウ
Title Alternative
Axonal dysfunction in diabetic neuropathy
Author
Kaji, Ryuji Division of Advanced Clinical Neuroscience, University Hospital, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
diabetic neuropathy
sodium channel
potassium channel
threshold electrotonus
latent addition
Content Type
Journal Article
Description
Diabetic neuropathy is characterized by the early decrease in motor conduction velocities and loss of vibratory sense. Autonomic dysfuncion may also be present in the early stage. These clinical features are not explainted by demyelination or Wallerian degeneration. Threshold tracking techniques such as latent addition or threshold electrotonus have been developed to explore the function of the ion channels non-invasively. Decreased peak Na current was found in diabetic patients, and is correlated with the decreased in motor conduction velocities. In ward rectifiers, which counteract membrane hyperpolatization, were found deficient in diabetic patients and models. This may lead to frequency-dependent conduction block, thus accounting for the early loss of vibratory sense. These clinical tests of axonal function is expected to reveal physiological information which the conventional nerve conduction studies could not provide previously.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
57
Issue
4-5
Start Page
117
End Page
124
Sort Key
117
Published Date
2001-10-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences