ID 110522
Title Transcription
Cガタカンエン ウイルス ジゾク カンセン カンジャ ノ カンセンイカ ニオケル ジョセイ ホルモン ノ ヤクワリ
Title Alternative
Estrogen and hepatic fibrosis in chronic HCV infection
Author
Shimizu, Ichiro Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine
Itonaga, Mina Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine
Lu, Guangming Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine
Cui, Xuezhi Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine
Toyota, Yoshio Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine
Kubo, Kenichiro Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine
Shinomiya, Hirohiko Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine
Tsutsui, Akemi Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine
Okahisa, Toshiya Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Shibata, Hiroshi Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine
Honda, Hirohito Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine
Ito, Susumu Department of Digestive and Cardiovascular Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory
Keywords
HCV
hepatic fibrosis
hepatic stellate cell
estradiol
estrogen receptor
Content Type
Journal Article
Description
The most common cause of hepatic fibrosis is chronic hepatitis C virus infection, the characteristic feature of which is hepatic steatosis. Hepatic steatosis leads to an increase in lipid peroxidation in hepatocytes, which in turn activates hepatic stellate cells (HSCs). HSCs are also thought to be the primary target cells for inflammatory stimuli, and produce extracellular matrix components. Clinical observations and death statistics support the view that chronic hepatitis C appears to progress more rapidly in men than in women, and cirrhosis is predominately a disease of men and postmenopausal women. It should be noted in this respect that estradiol (E2) is a potent endogenous antioxidant. Our studies showed that E2 suppressed hepatic fibrosis in hepatic fibrosis models, and attenuated HSC activation in primary culture. Recently, variant estrogen receptors (ERs) were found to be expressed to a greater extent in male patients with chronic liver disease than in female subjects. We also demonstrated decreased levels of ERs in postmenopausal women and cirrhotic patients of both genders. The present review summarizes our current knowledge of the biological functions of E2 and ER status as it relates to fibrogenesis in the liver.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
58
Issue
1-2
Start Page
22
End Page
34
Sort Key
22
Published Date
2002-04-25
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences