ID 110544
Title Transcription
セイタイ ボウギョ インシグン ノ ブンピツ オ ソクシン スル エンサンアンブロキソール ノ コウインフルエンザ コウカ
Title Alternative
Ambroxol suppresses influenza virus multiplication in the airway by increasing antiviral factor levels
Author
Nishikawa, Mai Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima
Yang, Bing Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima
Ide, Mikiko Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima
Okumura, Yuushi Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima
Kido, Hiroshi Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
influenza virus
ambroxol
pulmonary surfactant
tryptase clara
mucas protease inhibitor
Content Type
Journal Article
Description
Ambroxyol, known as a mucolytic agent, has been used for the treatment of chronic bronchitis and neonatal respiratory distress syndrome. Furthermore, ambroxol exhibits antioxidant and anti-inflammatory properties with reduction of the release of inflammatory cytokines. However, little is known about the pharmacological effect of ambroxol on influenza-virus infection in vivo. In this study, the protective effect of ambroxol against influenza-virus multiplication in the airway was investigated in mice. Ambroxol or the vehicle was administered intraperitonially twice a day for 5-7 days to mice shortly after intranasal infection with a lethal dose of influenza A/Aichi/68 (H3N2) virus, and the survival rate and levels of factors regulating virus multiplication in the airway fluid were analyzed. Ambroxol significantly suppressed virus multiplication and improved the survival rate of mice. Moreover, ambroxol stimulate the suppresors of infuluenza-virus multiplication, such as pulmonary surfactant, mucus protease inhibitor and IgA. These findings suggest that the effect of ambroxol on influenza-virus infection may result from the up-regulation of the suppressors. In this review, we discussed the effects of ambroxol on prevention and treatment of influenza virus infection.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
58
Issue
3
Start Page
162
End Page
167
Sort Key
162
Published Date
2002-06-15
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Institute of Advanced Medical Sciences