ID 110556
Title Transcription
2ガタ トウニョウビョウ カンジャ ノ ニョウチュウ アルブミン オヨビ ニョウチュウ ヨンガタ コラーゲン ニ カンスル リンショウテキ ケントウ : ドチラ ガ トウニョウビョウセイ ソウキ ジンショウ ノ ハッケン ニ ユウヨウカ
Title Alternative
A clinical study on urinary albumin and urinary type IV collagen in patients with type 2diabetes mellitus
Author
Mitani, Hiroaki Mitani Clinic
Keywords
Type 2 diabetic nephrophaty
urinary albumin and urinary type IV collagen
Content Type
Journal Article
Description
It is important that the control and the detect of diabetic early nephropathy are the first step of the protect of diabetic complications. In this study, in order to determine to be useful the predictor of diabetic nephropathy urinary albumin (creatinine ratio) and urinary type IV collagen were measured by LA and EIA methods in type 2 diabetes mellitus. The subjects are 215 patients with type 2 diabetes mellitus (Age : 65.9±10.8 yo.,Onset : 53.0±11.8 yo., Duration : 12.8±9.8 ys., BMI : 24.0±3.3 kg/m/m., HbA1c : 7.5±1.7%), and then urinary albumin (sigle voided) and urinary type IV collagen levels (first voided morning urine) were 116.0±294.2 mg/g. Cr and 5.88±4.20 g/g. Cr (mean±SD) respectively. To have compared with urinay albumin and urinary type IV collagen by treatments on the each groups, there were gradually increased Diat group < Glibenclamide (SU) group < Insulin therapy group, furthermore the factor of age ran pararell with clinial courses, but the duration of diabetes were not related with these proteinuria. The positive ratio of single voided urinary albumin in no clinical proteinuria were 18.3%, 11.0% for urinary type IV collagen, while in the diet group to be thought about the early stage of diabetic nephropathy, it’s positive ratio of urinary albumin were 52.5% and 38.5% for type IV urinary collagen respectively. Accordingly, in order to find out the early stage of diabetic nephropathy the sensitivity of the former was more than the later. These results sugest that the maker as the progreesion of early diabetic nephropathy might be useful to measure the single voided urinary albumin in comparrison with urinary type IV collagen.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
58
Issue
4-5
Start Page
220
End Page
226
Sort Key
220
Published Date
2002-10-25
FullText File
language
jpn
TextVersion
Publisher