ID 110578
Title Transcription
ジンエン シンコウ ニオケル サイボウガイ キシツ レセプター インテグリン ノ ヤクワリ ト ソノ キノウ セイギョホウ
Title Alternative
The role of β1-integrin family in the progression of glomerulonephritis
Author
Kagami, Shoji Deptartment of Pediatrics, Course of Human Development, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
integrin
extracellular matrix
remodeling
glomerulosclerosis
Content Type
Journal Article
Description
Sustained mesangial cell-mediated abnormal mesangial extracellular matrix (ECM) remodeling is the central biologic feature of progressive glomerulonephritis (GN) leading to glomerular sclerosis. Therefore, elucidating the molecular and cellular mechanisms involved in pathological mesangial remodeling is essential to understand the pathogenesis of progressive glomerular sclerosis. Accumulating evidences indicate that β1 integrin family regulate physiological and pathological ECM remodeling (fibrosis) in various organs. This overview will focus on our recent understanding of pathophysiological role of β1 integrin family in the progression of GN. Finally, we discuss the strategies targeting the integrin-mediated signaling pathway that permit the development of new therapeutic methods for inhibition of pathological ECM remodeling in GN.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
59
Issue
1-2
Start Page
14
End Page
18
Sort Key
14
Published Date
2003-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences