ID 110579
Title Transcription
ハイガン タゾウキ テンイ モデル ニヨル テンイ ノ ブンシ キコウ カイメイ ト チリョウ エノ オウヨウ
Title Alternative
Analysis of molecular pathogenesis of lung cancer metastasis using with multiple-organ metastasis models, and application for novel therapeutic modality
Author
Yano, Seiji Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima School of Medicine
Keywords
lung cancer
metastasis
organ environment
heterogeneity
molecular targeted drug
Content Type
Journal Article
Description
Lung cancer is a leading cause of malignancy-related death worldwide, and over 90% of deaths from lung cancer can be attributed to metastases. To explore molecular pathogenesis of lung cancer, we recently established multiple-organ metastasis models of human lung cancer cells in SCID mice depleted of NK cells. The pattern of metastasis in our models is similar with that observed in lung cancer patients. Using our models, we have shown that overexpression of cytokines, such as macrophage colony-stimulating factor and interleukin-10, resulted in organ-specific inhibition of metastasis by human lung cancer cell lines, suggesting differential regulation of metastasis by organ microenvironment. We further demonstrated that expression of human cancer cells were heterogenous, and that anti-metastastic effect of MMP inhibitor, a molecular targeted drug, could be organ specific, consistent with the results in recent clinical trials. Further intensive analyses using clinically relevant metastasis models (e.g., multiple-organ metastasis models) are warranted for establishment of novel, effective treatment for lung cancer metastasis.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
59
Issue
1-2
Start Page
19
End Page
24
Sort Key
19
Published Date
2003-04-25
FullText File
language
jpn
TextVersion
Publisher