ID 110580
Title Transcription
ゼンシンセイ エリテマトーデス ノ ゲンイン イデンシ ノ カイメイ ト ソレ ニ モトズク シンキ チリョウホウ ノ カノウセイ
Title Alternative
Defective antigen clearance and systemic lupus erythematosus
Author
Yasutomo, Koji Department of Immunology and Parasitology, The University of Tokushima, School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
systemic lupus erythematosus
T-cells
DNase1
self-antigen
Content Type
Journal Article
Description
Autoimmune diseases are caused by defective genes, aberrant gene expression or regulation, and environmental factors. Autoimmune disease susceptibility is determined by the interplay of these factors, which eventually affect autoreactive lymphocyte activation status or cell death sensitivity. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a broad variety of clinical symptoms and autoantibody production against nucleic acids, typically double-stranded DNA. Several lines of evidence indicate SLE development has a strong genetic basis. Recent studies have shown that most of the peripheral CD4+ or CD8+ T-cells have a potential to respond to self-antigens and persistence of such self antigens in vivo can provoke human or murine SLE. These recent findings in basic and clinical immunology would cause us to reconsider the importance of antigen clearance and persistence as a cause of SLE. Thus, I would like to review the lymphocyte abnormal responses seen in SLE patients from the view point of defective self-antigen clearance.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
59
Issue
1-2
Start Page
25
End Page
29
Sort Key
25
Published Date
2003-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
Medical Sciences