ID 110636
Author
Ewis, Ashraf A Department of Public Health, The University of Tokushima, School of Medicine|Department of Public Health and Occupational Medicine, School of Medicine, El-Minia University
Lee, Juwon Department of Public Health, The University of Tokushima, School of Medicine
Naroda, Takushi Department of Urology, The University of Tokushima, School of Medicine
Sasahara, Kenji Department of Public Health, The University of Tokushima, School of Medicine
Sano, Toshiaki Department of Pathology, The University of Tokushima, School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kagawa, Susumu Department of Urology, The University of Tokushima, School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Iwamoto, Teruaki Department of Urology, School of Medicine, St. Marianna University
Nakahori, Yutaka Department of Public Health, The University of Tokushima, School of Medicine
Keywords
prostate cancer
haplotypes
Y-chromosome
Japanese
DYS19
susceptibility
Content Type
Journal Article
Description
We studied the allele frequency distribution of the Y-chromosome linked tetranucleotide polymorphic microsatellite locus DYS19 in 90 prostate cancer Japanese patients from both Tokushima University hospital (Tokushima) and Saint Marianna University hospital (Kawasaki), Japan, comparing them to 99 matched male controls. Y-chromosomes from Japan as well as others from different geographical regions worldwide showed the five different alleles (A-E) with sizes varying from 186-202 bp, respectively. Comparison between DYS19 allelic frequency distribution among Japanese patients with prostate cancer and that of normal controls revealed significant differences regarding susceptibility or resistance to prostate cancer. We found that males with allele C of DYS19 are more susceptible to develop prostate cancer than males with other alleles (p=0.02). The Odds Ratio was 2.04 with a 95% confidence interval (0.75-2.42), compared with males having other alleles. In contrast, males with the D allele of DYS19 were less exposed to prostate cancer than other males (p=0.002); the Odds Ratio was 0.26 with a 95% confidence interval of (0.65-3.71). These findings support our hypothesis that male descendants from different Y-chromosomal origins are different regarding their susceptibility or resistance to develop prostate cancer (as a male-specific cancer).
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
49
Issue
1-2
Start Page
56
End Page
60
Sort Key
56
Published Date
2002
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences