ID 110649
Author
Maeda, Tomohiro
Motomura, Tadashi
Takano, Tamaki
Nonaka, Kenji
Linneweber, Joerg
Ichikawa, Seiji
Ishitoya, Hiroshi
Hanazaki, Kazuhiro
Glueck, Julie
Sato, Koshiro
Nose, Yukihiko
Keywords
hollow fiber
silicone membrane
oxygenator
extracorporeal membrane oxygenation
long-term ex vivo study
Content Type
Journal Article
Description
Currently in United States, there are no clinically-applicable hollow fiber extracorporeal membrane oxygenation (ECMO) oxygenators available. Therefore, our laboratory is in the process of developing a silicone hollow fiber membrane oxygenator for long-term ECMO usage. This oxygenator incorporates an ultrathin silicone hollow fiber. At this time, a specially-modified blood flow distributor (one chamber distributor) is centered in the module to prevent blood stagnation. An ex vivo long-term durability test for ECMO was performed using a healthy miniature calf for 2 weeks. Venous blood was drained from the left jugular vein of a calf, passed through the oxygenator and infused into the left carotid artery using a Gyro C1E3 centrifugal blood pump. A successful 2-week ex vivo experiment was performed. The O2 and CO2 gas transfer rates were maintained at the same value of 40 ml/min at a blood flow rate of 1 L/min flow and V/Q=3 (V=gas flow rate Q=blood flow rate). The plasma free hemoglobin was maintained around 5 mg/dl. After the experiment, no blood clot formation was observed in the module and no abnormal necropsy findings were found. These data suggest that the performance of this newly-improved oxygenator was stable, reliable, and acceptable for long-term ECMO.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
49
Issue
3-4
Start Page
156
End Page
162
Sort Key
156
Published Date
2002
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences