ID 110650
Author
Kamamura, Masako Second Department of Internal Medicine, The University of Tokushima School of Medicine
Honda, Hirohito Second Department of Internal Medicine, The University of Tokushima School of Medicine
Inoue, Hiroshi Second Department of Internal Medicine, The University of Tokushima School of Medicine
Shinomiya, Hirohiko Second Department of Internal Medicine, The University of Tokushima School of Medicine
Kubo, Kenichiro Second Department of Internal Medicine, The University of Tokushima School of Medicine
Tsutsui, Akemi Second Department of Internal Medicine, The University of Tokushima School of Medicine
Muguruma, Naoki Second Department of Internal Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Shibata, Hiroshi Second Department of Internal Medicine, The University of Tokushima School of Medicine
Shimizu, Ichiro Second Department of Internal Medicine, The University of Tokushima School of Medicine
Ito, Susumu Second Department of Internal Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory
Keywords
HCV
chronic liver diseases
chronic hepatitis C
regional differences
hepatocellular carcinoma
Content Type
Journal Article
Description
Mortality rates from chronic liver diseases (CLD) such as liver cirrhosis and hepatocellular carcinoma have been reported to be higher in Tokushima prefecture, although its causes remain unclear. To clarify the causes of CLD in Tokushima prefecture, we evaluated the positive rates of HBs antigen and anti-HCV antibody and the mortality rates from CLD in patients with liver diseases and blood donors after dividing the entire Tokushima prefecture into 8 district boundaries of health centers. In addition, to evaluate the causes of the higher frequency of CLD and the relationship between the development of CLD and viruses, medical examinations were performed in 2 mountain villages in Tokushima prefecture where the drift of population was limited and the mortality rates from CLD differed from each other. As a result, it was found that HCV infection was the major cause of the higher mortality rates from CLD in Tokushima prefecture. Although there were marked regional differences in the mortality rates from CLD, they were mainly due to different rates of HCV infection.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
49
Issue
3-4
Start Page
163
End Page
171
Sort Key
163
Published Date
2002
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences