ID 110658
Author
Rokutan, Kazuhito Department of Nutritional Physiology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hirakawa, Tetsuya Department of Parasitology, The University of Tokushima School of Medicine
Teshima, Shigetada Department of Nutritional Physiology, The University of Tokushima School of Medicine KAKEN Search Researchers
Nakano, Yoko Department of Biology, Tsukuba Laboratories for Drug Discovery, Eisai Co.
Miyoshi, Mami Department of Nutritional Physiology, The University of Tokushima School of Medicine
Kawai, Tomoko Department of Nutritional Physiology, The University of Tokushima School of Medicine
Konda, Emi Department of Nutritional Physiology, The University of Tokushima School of Medicine
Morinaga, Hiroko Department of Nutritional Physiology, The University of Tokushima School of Medicine
Nikawa, Takeshi Department of Nutritional Physiology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kishi, Kyoichi Department of Nutritional Physiology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
heat shock / stress proteins
physiologic stress
stress ulcer
ischemic tolerance
chaperone inducers
Content Type
Journal Article
Description
Heat shock/ stress proteins (HSPs) are crucial for maintenance of cellular homeostasis during normal cell growth and for survival during and after various cellular stresses. The HSP70 family functions as molecular chaperones and reduces stress-induced denaturation and aggregation of intracellular proteins. In addition to the chaperoning activities, HSP70 has been suggested to exert its protective action by protecting mitochondria and by interfering with the stress-induced apoptotic program. The biochemical and functional properties of HSPs observed in cultured cells may be relevant to organs and tissues in whole animals. The activation of the hypothalamic-pituitary-adrenal axis and the sympathetic nerve system elicits the stress response in selected peripheral tissues the HSP70 expression in the vasculature and stomach increases resistance against hemodynamic stress and stress-induced mucosal damage, respectively. Gastric mucosa pretreated with mild irritants acquires a tolerance against subsequent mucosal-damaging insults. This phenomenon is known as “adaptive cytoprotection”. Transient ischemia also induces ischemic tolerance in the brain and heart, which is called “ischemic preconditioning”. The heat shock response is believed to contribute to the acquisition of the tolerance. The therapeutic applications of chaperone inducers that induce HSPs without any toxic effect are also introduced.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
44
Issue
3-4
Start Page
137
End Page
147
Sort Key
137
Published Date
1998
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences