ID 110668
Author
Parajuli, Prahlad Third Department of Internal Medicine, University of Tokushima School of Medicine
Yano, Seiji Third Department of Internal Medicine, University of Tokushima School of Medicine
Hanibuchi, Masaki Third Department of Internal Medicine, University of Tokushima School of Medicine KAKEN Search Researchers
Nokihara, Hiroshi Third Department of Internal Medicine, University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory
Shinohara, Tsutomu Third Department of Internal Medicine, University of Tokushima School of Medicine
Sone, Saburo Third Department of Internal Medicine, University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Macrolide
human lung cancer
metastasis
SCID mice.
Content Type
Journal Article
Description
Recently, the use of macrolides is suggested to be therapeutically effective in prolonging the survival of patients with inoperable non-small cell lung cancer. The purpose of this study was to examine therapeutic effects of a macrolide, clarythromycin (CAM) on the metastastic developments of two different human non-small cell lung cancers (squamous cell lung carcinoma RERF-LC-AI, and adenocarcinoma PC-14) in severe combined immunodeficient (SCID) mice depleted or undepleted of natural killer (NK) cells, respectively. CAM, injected subcutaneously at doses of 5 and 10 mg/kg body weight/day from day 7 to 41 after i.v. inoculation of human lung cancer cells, was not effective in inhibiting their distant organ metastases in SCID mice. CAM at concentrations of less than 10 μg/ml did not have a direct influence on the proliferation of these tumor cells in vitro. Although CAM alone was not effective in augmenting NK activity, it augmented the IL-2-induced killer (LAK) activity against Daudi cells in vitro. These results suggest that CAM alone may not be enough to control the spread of non-small cell lung cancer in the patient with T cell dysfunction.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
44
Issue
3-4
Start Page
205
End Page
210
Sort Key
205
Published Date
1998
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital