ID 110669
Author
Akari, Hirofumi Department of Virology, The University of Tokushima School of Medicine
Yamamoto, Yoshihiko Department of Virology, The University of Tokushima School of Medicine
Hiwada, Hiroko Department of Virology, The University of Tokushima School of Medicine
Saito, Yasuyoshi Institute for Life Science Research, Asahi Chemical Industry Co. Ltd.
Takayanagi, Noriyasu Institute for Life Science Research, Asahi Chemical Industry Co. Ltd.
Koyama, A. Hajime Department of Virology, The University of Tokushima School of Medicine
Adachi, Akio Department of Virology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
fasudil
protein kinase inhibitor
HIV-1
Content Type
Journal Article
Description
Fasudil is a potent inhibitor for various protein kinases such as myosin light chain kinase and protein kinase C. It has been used as a drug for improvement of intracranial vasospasm and following ischaemic diseases. In this report, we demonstrate that fasudil suppressed the replication of human immunodeficiency virus type 1 (HIV-1) in mitogen-activated peripheral blood mononuclear cells. Our finding shows that fasudil may be useful as a new and distinct chemotherapeutic agent against HIV-1 infection.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
44
Issue
3-4
Start Page
211
End Page
214
Sort Key
211
Published Date
1998
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences