ID 110670
Author
Ozaki, Shuji First Department of Internal Medicine, The University of Tokushima School of Medicine
Ogasahara, Koji First Department of Internal Medicine, The University of Tokushima School of Medicine
Kosaka, Masaaki First Department of Internal Medicine, The University of Tokushima School of Medicine
Inoshita, Toshi First Department of Internal Medicine, The University of Tokushima School of Medicine
Wakatsuki, Shingo First Department of Pathology, The University of Tokushima School of Medicine
Uehara, Hisanori Second Department of Pathology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Matsumoto, Toshio First Department of Internal Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
hepatosplenic lymphoma
γδT-cell
hepatitis B virus
chronic hepatitis
hepatosplenomegaly
Content Type
Journal Article
Description
Hepatitis B virus (HBV) infection has been implicated in the development of hepatocellular and hematopoietic malignancies. We describe a patient with chronic hepatitis B who developed hepatosplenic γδT-cell lymphoma. A 45-year-old woman presented with marked hepatosplenomegaly and hepatic failure during the course of chronic hepatitis B. Peripheral blood examination revealed57% abnormal lymphoid cells which expressed the γδT-cell receptor. The cytogenetic analysis of tumor cells showed an abnormal karyotype 47, XX, -13, +2mar in all 20 metaphases examined. A clonal rearrangement of the T-cell receptor genes was demonstrated by Southern blot analysis, showing monoclonal expansion of tumor cells. A liver biopsy specimen showed fibrosis of the portal areas and sinusoidal infiltration of tumor cells. HBV infection was documented by the presence of IgG anti-HBc and anti-HBs antibodies in serum. Although HBV-DNA was not detected in tumor cells by polymerase chain reaction analysis, there is a possibility that proliferation of γδT cells in response to HBV infection played a role in the pathogenesis of hepatosplenic γδT-cell lymphoma.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
44
Issue
3-4
Start Page
215
End Page
217
Sort Key
215
Published Date
1998
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Institute of Advanced Medical Sciences