ID 110677
Author
Urakami, Yoshihito Department of Gastroenterology, Urakami Gastro Clinic
Sano, Toshiaki Department of Pathology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
gastric metaplasia
Helicobacter pylori
duodenal ulcer
eradication
Content Type
Journal Article
Description
Backgrounds and Aims : There is no commonly accepted view concerning changes in gastric metaplasia after the eradication of Helicobacter pylori. The aim of this study was to evaluate the long-term course of gastric metaplasia after the eradication of this bacterium. Methods : The subjects were 59 patients with duodenal ulcer who were positive for Helicobacter pylori. Forty patients were classified as the eradication group. Gastric metaplasia was endoscopically and histologically evaluated before and after eradication of this bacterium. The follow-up period was 2-7.1 years. In the other 19 patients in the non-eradication group, gastric metaplasia was evaluated before and after treatment of the ulcer. Gastric metaplasia was evaluated in terms of its extent and type in all patients. Results : Gastric metaplasia showed the incomplete type before eradication but changed to the complete type after eradication, which persisted for a long period. The extent of gastric metaplasia increased after eradication. In the non-eradication group, gastric metaplasia infrequently changed to the complete type during the scarring period of ulcer. Conclusion : Gastric metaplasia changed to the complete type after the eradication of Helicobacter pylori, which persisted for a long period.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
50
Issue
1-2
Start Page
48
End Page
54
Sort Key
48
Published Date
2003
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences