ID 110679
Author
Matsunaga, Hiroko Second Department of Internal Medicine, The University of Tokushima School of Medicine
Honda, Hirohito Second Department of Internal Medicine, The University of Tokushima School of Medicine
Kubo, Kenichirou Second Department of Internal Medicine, The University of Tokushima School of Medicine
Sannomiya, Katsutaka Second Department of Internal Medicine, The University of Tokushima School of Medicine
Cui, Xuezhi Second Department of Internal Medicine, The University of Tokushima School of Medicine
Toyota, Yoshio Second Department of Internal Medicine, The University of Tokushima School of Medicine
Mori, Toshifumi Second Department of Internal Medicine, The University of Tokushima School of Medicine
Muguruma, Naoki Second Department of Internal Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Okahisa, Toshiya Second Department of Internal Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Okamura, Seisuke Second Department of Internal Medicine, The University of Tokushima School of Medicine
Shimizu, Ichiro Second Department of Internal Medicine, The University of Tokushima School of Medicine
Ito, Susumu Second Department of Internal Medicine, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory
Keywords
chronic hepatitis
HCV
guanase
ALT
Content Type
Journal Article
Description
The study examines the clinical significance of guanase (GU) measurement inpatients with hepatitis C. 688 patients in whom either ALT was abnormal, or in whom HBsAg or HCVAb was detected in the serum, were enrolled into this study. The percentage of cases in which normal ALT while elevated GU was compared among the different disease groups. Then, the percentage of cases with normal ALT but elevated GU was compared between HBV and HCV groups. For the entire population, a significant correlation was observed between ALT and GU (r=0.872). The overall percentage of cases with normal ALT but elevated GU activity was 11.4%. In HCV group, 449 cases had normal ALT. Of these cases, 20.3% had elevated GU, while ALT was normal. Before 1989, no test to check donated blood for HCV antibody was available. However, screening of donated blood for high GU was associated with a reduced incidence of post-transfusion hepatitis. This is probably because following the screening, blood donated by patients with hepatitis C who had normal ALT but elevated GU was rejected. After the introduction of HCV antibody measurement, GU measurement is still useful to reveal the pathophysiological condition in-patients with chronic hepatitis type C.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
50
Issue
1-2
Start Page
64
End Page
71
Sort Key
64
Published Date
2003
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences