ID 110686
Author
Matsumoto, Kazuya Departments of Plastic and Reconstructive Surgery, The University of Tokushima School of Medicine
Nakanishi, Hideki Departments of Plastic and Reconstructive Surgery, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kubo, Yoshiaki Department of Dermatology, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yokozeki, Masahiko Department of Orthodontics, The University of Tokushima School of Dentistry
Moriyama, Keiji Department of Orthodontics, The University of Tokushima School of Dentistry
Keywords
distraction osteogenesis
craniofacial skeleton
Content Type
Journal Article
Description
Distraction osteogenesis has been applied to the craniofacial skeleton as well as the long bones of the extremities. This technique does not require bone grafting and allows correction of craniofacial deformities with less invasion. Moreover, the distraction procedures can expand the overlying soft tissues simultaneously. We determined the indications of distraction osteogenesis, analyzed the types of devices available, and examined patients treated with distraction for the mandible, midface, and cranium. In all three sites, the devices tended to be the buried type and made of absorbable materials. Administration of some cytokines for shortening the consolidation period may be considered. Among disorders indicated for distraction osteogenesis, there are several syndromic craniosynostoses, which involve mutations in the fibroblast growth factor receptor (FGFR) 2 gene. The FGFR2 mutation was suggested to clinically accelerate osteogenesis at the distraction site. The usefulness and appropriateness of the distraction protocol must be assessed for each individual disorder. Although distraction osteogenesis in the craniofacial skeleton has advanced technologically, all possible risks must be discussed with the patient and family members when obtaining preoperative informed consent, especially until establishment of fully safe distraction procedures.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
50
Issue
3-4
Start Page
117
End Page
125
Sort Key
117
Published Date
2003
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences