Yang, Xin-Jun Department of Human Genetics and Public Health, Graduate School of Proteomics, The University of Tokushima
Yan, Hong-Tao Department of Human Genetics and Public Health, Graduate School of Proteomics, The University of Tokushima
Nakahori, Yutaka Department of Human Genetics and Public Health, Graduate School of Proteomics, The University of Tokushima
laser in situ keratomileusis (LASIK)
photorefractive keratectomy (PRK)
Objective: To evaluate the effectiveness of laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) for correcting myopia. Methods : Study selection, data extraction, and quality assessment were performed by two of authors independently. Summary odds ratios and 95% confidence intervals were calculated by DerSimonian amp Laird random-effects model and Mantel-Haenszel (fixed-effects) model. All calculations were based on an intention-to-treat and per protocol analysis. Results : Five hundred and eighty eyes (476 patients) from5 randomized controlled trials were included in this study. At≧6 months follow-up, by random-effects model, the pooled odds ratios (OR, for LASIK vs. PRK) of postoperative uncorrected visual acuity (UCVA) of 20/20 or better for all trials were 1.31 (95% CI=0.77-2.22) by per protocol analysis and 1.18 (95%CI=0.74-1.88) by intention-to-treat analysis. In the refractive outcome, the pooled OR of the postoperative spherical equivalent refraction within±0.5diopter (D) of emmetropia didnot show any statistical significance, for which the OR were 0.75 (95% CI=0.48-1.18) by per protocol analysis and 0.70 (95% CI=0.47-1.04) by intention-to-treat analysis. Conclusions : LASIK and PRK were found to be similarly effective for the correction of myopia from-1.5 to -15.0 D in a greater than 6 month follow-up.
The journal of medical investigation : JMI
jmi_50_3-4_180.pdf 282 KB