ID 110712
Author
Kinoshita, Hiroshi Department of Legal Medicine, Hyogo College of Medicine
Ijiri, Iwao Department of Forensic Medicine, Kagawa Medical University
Ameno, Setsuko Department of Forensic Medicine, Kagawa Medical University
Hishida, Shigeru Department of Legal Medicine, Hyogo College of Medicine
Ameno, Kiyoshi Department of Forensic Medicine, Kagawa Medical University
Keywords
acetaldehyde
ethanol
hexamethonium
intestinal absorption
yohimbine
Content Type
Journal Article
Description
In the present study, we investigated the effects of hexamethonium, a ganglionic nicotinic receptor blocking agents and yohimbine, an α2-adrenergic antagonist, on reduction of ethanol absorption in presence of high acetaldehyde concentration. Hexamethonium had no effect, whereas yohimbine by itself reduced ethanol absorption, but no additional effects were observed with presence of high acetaldehyde. Propionaldehyde had an inhibitory action on intestinal 1-propanol absorption. As both yohimbine and propionaldehyde are associated with vagus nerve activation, these results indirectly support the hypothesis that a cholinergic mechanism through vagus nerve activation is responsible for the inhibition of intestinal ethanol absorption by acetaldehyde.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
51
Issue
1-2
Start Page
38
End Page
42
Sort Key
38
Published Date
2004-02
FullText File
language
eng
TextVersion
Publisher