ID 110726
Author
Sasaki, Katsuya Department of Digestive Pediatric Surgery, The University of Tokushima School of Medicine
Miyake, Hidenori Department of Digestive Pediatric Surgery, The University of Tokushima School of Medicine
Kinoshita, Takafumi Department of Digestive Pediatric Surgery, The University of Tokushima School of Medicine
Ikeyama, Shizuo Department of Digestive Pediatric Surgery, The University of Tokushima School of Medicine
Tashiro, Seiki Department of Digestive Pediatric Surgery, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory
Keywords
ischemia-reperfusion injury
non-heart-beating donor
orthotopic liver transplantation
FK 506
OKY046
Content Type
Journal Article
Description
The study investigated the possibility of pharmacologically modulating hepatic allograft function from non-heart-beating donors (NHBDs)using male Lewisrats. The donors were divided into 4 groups :Group 1 in which the vehicle was administered, Group 2 in which FK506 (tacrolimus a powerful immunosuppressive agent)was administered,Group3 in which OKY046 (a specific thromboxane synthetase inhibitor) was administered and Group 4 in which FK506 and OKY046 were administered. The recipients received orthotopic liver transplantation. The survival rates differed significantly between the recipients that had received liver transplantation from Groups1 and 4. The serum liver enzyme and inflammatory cytokine concentrations of the recipients which had received liver transplantation from Groups 2, 3 and 4 were significantly lower than those of the recipients that had received liver transplantation from Group1. Although there was no significant difference, all parameters were better in the recipients that had received transplantation from Group 4 than those that had received transplantation from Groups 2 and 3. The action mechanisms of FK506 and OKY046 are completely different. Therefore, concomitant use of FK506 and OKY046 might have additive effects on liver transplantation from NHBDs. In conclusion, we demonstrated that pretreatment of NHBDs using FK506 and OKY 046 ameliorated graft viability.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
51
Issue
1-2
Start Page
76
End Page
83
Sort Key
76
Published Date
2004-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences