ID 110743
Author
Terazawa, Toshihide Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine
Miyake, Hidenori Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine
Kurahashi, Miho Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine
Tashiro, Seiki Department of Digestive and Pediatric Surgery, The University of Tokushima School of Medicine Tokushima University Educator and Researcher Directory
Keywords
gallbladder
lymphatic drainage
gallbladder carcinoma
heptic invasion
pig
Content Type
Journal Article
Description
In the special occasion that the physiological lymphatic flow is obstructed, gallbladder carcinoma (GBC)may spread into the liver via lymphatic route. Therefore, this study was conducted to find out the direct lymphatic route draining into the liver from the gallbladder using pigs with ligated cystic ducts. After injecting the carbon particle suspension (CH40) or the contrast medium (Lipiodol) into the subserosal layer of the gallbladder, the lymphatic route into the liver was examined both macroscopically and histologically. In controls, CH40 or Lipiodol drained along the cystic duct toward the hepatoduodenal ligament. After occlusion of cystic duct, CH40 was interrupted at the ligated point, and then spread into the liver nearby the gallbladder bed, running off to the liver hilus, toward the hepatoduodenal ligament. This route was confirmed by the Lipiodol drainage into the right median lobe of the liver, equivalent to the segments Vand IV a in humans. We presented for the first time the emergence of lymphatic drainage from the gallbladder into the liver after the occlusion of physiological lymphatic route using pigs. This implies that the direct spread into the segments Vand IVa of liver should be considered in the surgical treatment of advanced GBC.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
51
Issue
3-4
Start Page
210
End Page
217
Sort Key
210
Published Date
2004-08
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences