ID 110769
Author
Rokutan, Kazuhito Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School|Human Stress Research Center, University of Tokushima|The Research Institute of Science and Technology for Science of Japan Science and Technology Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Morita, Kyoko Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School|Human Stress Research Center, University of Tokushima
Masuda, Kiyoshi Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN Search Researchers
Tominaga, Kumiko Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School
Shikishima, Michiyo The Research Institute of Science and Technology for Science of Japan Science and Technology
Teshima-Kondo, Shigetada Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School|Human Stress Research Center, University of Tokushima KAKEN Search Researchers
Omori, Tetsuro Department of Psychiatry, Institute of Health Biosciences, The University of Tokushima Graduate School|Human Stress Research Center, University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sekiyama, Atsuo Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School
Keywords
stress
allostasis
hypothalamus-pituitary-adrenal axis
stress assessment
microarray
Content Type
Journal Article
Description
Stress is the coordinated physiological processes to maintain a dynamic equilibrium under stressful conditions. The equilibrium is threatened by certain physiological and psychological stressors. Stressors trigger physiological, behavioural, and metabolic responses that are aimed at reinstating homeostasis. The hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system play an essential role in the stress response. Excessive, prolonged, or inadequate response that is termed as “allostasis” or “allostatic load” leads to pathological outcomes. Dysregulation of the HPA axis activity is involved in the pathogenesis of stress related disorders including major depression. The complex brain-immune-endocrine network regulates the HPA axis, and hereditary predisposition as well as environmental factors such as traumatic experiences in early life also modifies the capacity of an individual to cope. Therefore, it is difficult to correctly assess the complex stress response. We have developed a microarray carrying 1,467 cDNAs that were selected to specifically measure stress response in peripheral blood leukocytes. Using this tool, we have succeeded to objectively assess individual response to acute psychological stress and to detect unique expression profiles in patients with depression. Gene expression profile in peripheral blood leukocytes may be a potentially useful for the detection of disease-associated, abnormal stress responses.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
52
Issue
3-4
Start Page
137
End Page
144
Sort Key
137
Published Date
2005-08
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences