ID 110771
Author
Liu, Weiping Department of Neurological Surgery, Faculty of Medicine, Kagawa University
Matsumoto, Yoshihito Department of Neurological Surgery, Faculty of Medicine, Kagawa University
Okada, Masaki Department of Neurological Surgery, Faculty of Medicine, Kagawa University
Miyake, Keisuke Department of Neurological Surgery, Faculty of Medicine, Kagawa University
Kunishio, Katsuzo Department of Neurological Surgery, Faculty of Medicine, Kagawa University
Kawai, Nobuyuki Department of Neurological Surgery, Faculty of Medicine, Kagawa University
Tamiya, Takashi Department of Neurological Surgery, Faculty of Medicine, Kagawa University
Nagao, Seigo Department of Neurological Surgery, Faculty of Medicine, Kagawa University
Keywords
MMP-2
MMP-9
Ki-67
pituitary adenomas
tumor invasion
Content Type
Journal Article
Description
Object :Matrix metalloproteinase (MMP) 2 and 9 are important for tissue breakdown in the process of tumor invasion. The aim of this study is to evaluate the relationship between the expression of MMP-2, MMP-9,MIB-1 LI and cavernous sinus invasion in pituitary adenomas. Methods : Tissue samples from54 patients with pituitary adenomas were studied. Expression of MMP-2, MMP-9, and MIB-1 labeling index (LI) were evaluated by immunohistochemical method. In sixteen cases, the expression of MMP-2 and MMP-9 mRNA was also examined by RT-PCR assay. Results : Thirty-four patients were women and 20 were men, with a mean age of 49.9 years old (range 18-76 years). There were 12 cases with cavernous sinus invasion, and 42 were noninvasive cases. MMP-2 and MMP-9 score of invasive case (3.9±0.5, 4.1±0.4)were significantly higher than those (2.3±0.2 p<0.01 2.6±0.2 p<0.01) without invasion. The MIB-1 LI of this study presented no significantly difference between the invasive and noninvasive pituitary adenomas. The percentage of MMP-2 mRNA/β-actin mRNA and MMP-9 mRNA/β-actin mRNA were also observed significantly higher in invasive pituitary adenomas (68.2±15.3 % 59.7±12.5 %) than noninvasive pituitary adenomas (21.8±8.2 % , p<0.05 33.3±5.4 % , p<0.05). Conclusions : Our study suggests that the expression of MMP-2 and MMP-9 may have a value to assess the invasive pituitary adenomas, and proliferation and invasion of pituitary adenomas may present a different mechanism.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
52
Issue
3-4
Start Page
151
End Page
158
Sort Key
151
Published Date
2005-08
FullText File
language
eng
TextVersion
Publisher