ID 110785
Author
Sakai, Tohru Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School|Department of Clinical Nutrition, Osaka Prefecture University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kogiso, Mari Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School
Mitsuya, Kaori Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School
Komatsu, Tatushi Department of Clinical Nutrition, Osaka Prefecture University
Yamamoto, Shigeru Department of International Public Health Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Keywords
NC/Nga mice
oral tolerance
antigen
antibody
ovalbumin
Content Type
Journal Article
Description
The NC/Nga mouse is a model animal for human atopic dermatitis. In this study, we investigated oral tolerance induction in NC/Nga mice. In BALB/c mice, oral administration of ovalbumin (OVA) resulted in suppression of both OVA-specific T and B cell responses induced by OVA immunization. In NC/Nga mice, OVA-induced antigen (Ag) -specific T and B cell responses were significantly less than those in BALB/c mice. Furthermore, oral administration of OVA did not suppress OVA-specific immunoresponses in NC/Nga mice. We further examined antibody (Ab) response against food Ag by feeding mice an experimental diet that contained OVA or casein as a protein source. The level of serum OVA or casein-specific IgG was significantly higher in NC/Nga mice than in BALB/c mice. These results indicate that NC/Nga mice have a defect in the induction of oral tolerance. NC/Nga mice can therefore be used as a model for investigating the mechanism of oral tolerance.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
53
Issue
1-2
Start Page
29
End Page
33
Sort Key
29
Published Date
2006-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences