ID 110792
Author
Koshiba, Kunihiko Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School
Nomura, Masahiro Faculty of Integrated Art and Sciences, Department of Human and Social Sciences, The University of Tokushima Graduate School
Nakaya, Yutaka Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ito, Susumu Department of Nutrition and Metabolism, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Keywords
glimepiride
insulin resistance
adipocytokines
atherosclerosis
Content Type
Journal Article
Description
Background : Plasma adiponectin levels increase after the administration of glimepiride. This unique effects would also be expected to improve other adipocytokines and have antiatherosclerotic action in patients with metabolic syndrome. Methods : Thirty-four patients with type 2 diabetes mellitus who were administrated glibenclamide were randomly divided into two groups. In20patients glibenclamide was changed to glimepiride (GP group), and the administration of glibenclamide (GB group) was continued in 14 patients. Twelve patients receiving insulin therapy (INS group) were enrolled for comparison. The levels of plasma adiponectin, high sensitive-CRP, TNF-α, interleukin-6, homeostasis model assessment-insulin resistance (HOMA-IR), brachial-ankle pulse wave velocity (baPWV) and augmentation index (AI) were measured before and 28 weeks after the therapy. Results: HOMA-IR in the GP group was significantly decreased compared to the GB group. Plasma adiponectin levels were significantly increased in the GP group but not in the other groups. TNF-α, interleukin-6 and high sensitive-CRP levels were significantly decreased in the GP group, but not in the other groups. The baPWV and AI levels did not change in either the GB or the INS group, but were significantly decreased in the GP group. Conclusions: Glimepiride appears to improve insulin resistance and atherosclerotic disorders.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
53
Issue
1-2
Start Page
87
End Page
94
Sort Key
87
Published Date
2006-02
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences