ID 110820
Author
Shimooka, Rie Department of Nutrition and Health Promotion, Faculty for Human Life Science, Hiroshima Jogakuin University
Kido, Yasuhiro Department of Food Sciences and Nutritional Health, Faculty of Human Environment, Kyoto Prefectural University
Chiba, Naoko Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
Tanaka, Junko Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
Rokutan, Kazuhito Department of Stress Science, Institute of Proteomics Medical Science, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Furochi, Harumi Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
Hirasaka, Katsuya Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN Search Researchers
Nikawa, Takeshi Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kishi, Kyoichi Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
cystathionine γ-lyase
methionine
portacaval shunted rats
soy protein diet
Content Type
Journal Article
Description
In hepatic disorders, abnormal plasma amino acid profiles are observed. In this study, we examined whether soy protein isolate (SPI) improved plasma methionine concentration in the model animals. Portacaval shunt (PCS) increased alanine aminotransferase (ALT) activity and methionine concentration in blood of rats fed a 40% casein diet supplemented with 0.6% methionine (casein-M diet). A 40% SPI diet supplemented with 1.28% methionine (SPI-M diet), which contained the same amount of methionine as that in 40% casein-M diet, normalized plasma ALT activity and methionine level in PCS rats. These effects of a SPI diet may be due to its amino acid composition, since an amino acid mixture diet mimicking a 40% SPI-M diet was also effective to hypermethioninemia of PCS rats. To find key enzymes for the beneficial effect of soy protein, we examined effects of a 40% SPI-M or casein-M diet on the activities of three methionine-metabolizing enzymes in liver of PCS rats. A SPI-M diet stimulated only the activity of cystathionine γ-lyase, compared with a casein-M diet. A SPI diet has a preventive effect on hypermethioninemia, at least in part, by stimulating cystathionine γ-lyase activity in liver and may be used for nutritional management of liver disorders with hypermethioninemia.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
53
Issue
3-4
Start Page
255
End Page
263
Sort Key
255
Published Date
2006-08
EDB ID
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences