ID 110828
Author
Tsujikawa, Tetsuya Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School|Biomedical Imaging Research Center University of Fukui
Nomura, Masahiro Faculty of Integrated Art and Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Nakayasu, Kimiko Faculty of Integrated Art and Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Kawano, Tomohito Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
Nakaya, Yutaka Department of Nutrition and Metabolism, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ito, Susumu Department of Digestive and Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Nishitani, Hiromu Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
acute coronary syndrome
MDCT
soft plaque
Content Type
Journal Article
Description
Purpose: The acute coronary syndrome is often caused by the rupture of plaques and thrombus formation even without significant stenosis, and patients with soft plaques, but without significant stenosis evidenced by coronary angiography(CAG), often develop an acute coronary syndrome. To address this discrepancy, a qualitative diagnosis of coronary plaques using a 16 slice multidetector-row CT was conducted.
Methods and Results: Volume rendering and cross-sectional MPR images were obtained. Based on the CT values, plaques on the coronary artery wall were classified as lipid-rich soft plaques(CT value<50 HU) and non-soft plaques (>50 HU) .
A significant correlation was observed between the percent stenosis determined in crosssectional MPR images and those determined by CAG(r=+0.92, p<0.01). Diffuse plaques with CT values of less than 50 HU often caused stenosis at level of 75% or less, which were not indicated by percutaneous transluminal coronary angioplasty.
Conclusions : Although diffuse soft plaques with CT values less than 50 HU are not an indication of intervention, a risk of an acute coronary syndrome exists, due to rupture. These soft plaques must be stabilized by treatment even when they do not cause significant stenosis, and MDCT is considered to be useful for their evaluation.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
53
Issue
3-4
Start Page
310
End Page
316
Sort Key
310
Published Date
2006-08
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences