ID 110829
Author
Miyamoto, Hidenori Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
Kurita, Nobuhiro Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN Search Researchers
Nishioka, Masanori Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
Ando, Tsutomu Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
Tashiro, Takashi Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
Hirokawa, Mitsuyoshi Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School
Shimada, Mitsuo Department of Digestive and Pediatric Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
neuroendocrine cell carcinoma
rectum
Ki-67
Content Type
Journal Article
Description
A 56-year-old man was admitted to our hospital because of anal bleeding. Colonoscopy and barium enema revealed type 4 tumor in the rectum. Biopsy revealed poorly differentiated adenocarcinoma. Low anterior resection with total mesorectal excision and lymph node dissection was performed. In immunohistochemical staining, chromogranin A and synaptophysin were positive at major lesion, and CEA were focal positive. The resected tumor was diagnosed pathologically as neuroendocrine cell carcinoma. The Ki-67 labeling index (LI) was 87.8%, so proliferative activity and potential malignancy was very high. Multiple metastatic tumors appeared in pelvis and lung eight months after operation. Treatment for neuroendocrine cell carcinoma of the rectum was controversial. Surgical resection and adjuvant chemotherapy might be one of the methods for gastrointestinal neruroendocrine cell carcinoma.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
53
Issue
3-4
Start Page
317
End Page
320
Sort Key
317
Published Date
2006-08
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences