ID 110846
Author
Tanimoto, Shuji Department of Urology, Takamatsu Red Cross Hospital
Fukumori, Tomoharu Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
El-Moula, Gad Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Shiirevnyamba, Avirmed Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Kinouchi, Shinichiro Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Koizumi, Takahiro Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Nakanishi, Ryoichi Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Yamamoto, Yasuyo Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Taue, Ryuichi Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Yamaguchi, Kunihisa Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakatsuji, Hiroyoshi Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Kishimoto, Tomoteru Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Izaki, Hirofumi Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN Search Researchers
Oka, Natsuo Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School
Takahashi, Masayuki Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kanayama, Hiro-omi Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
renal cell carcinoma
hepatocyte growth factor
vascular endothelial growth factor
prognostic maker
diagnostic maker
Content Type
Journal Article
Description
No adequate serum predictive biomarker currently exists, which can identify the activity of renal cell carcinoma (RCC). We investigate the association of serum hepatocyte growth factor (HGF) and serum vascular endothelial growth factor (VEGF) levels with clinicopathologic parameters in untreated clear cell RCC patients. We measured serum levels of HGF and VEGF in 45 patients with untreated clear cell RCC and 45 healthy controls using an enzyme-linked immunosorbent assay (ELISA). Patients with clear cell RCC had significantly higher serum HGF and VEGF concentrations than healthy subjects : median, 1070.7 versus 728.3 pg/ml (p<0.0001) for HGF and median, 397.5 versus 245.6 pg/ml (p=0.0003) for VEGF. We found a significant correlation between serum level of HGF and clinical stage and tumor grade. Survival of patients with high serum HGF (>1150 pg/ml) was significantly reduced compared to patients with low serum HGF concentrations (p=0.0044). In patients with nuclear grade 2 or high stage RCC, the higher serum HGF group exhibited significantly lower cause-specific survival (p= 0.0087 and p<0.05, respectively). No significant difference was observed between serum VEGF levels and cause-specific survival rate. Serum HGF might be a diagnostic and prognostic indicator in clear cell RCC, especially for patients with grade 2 or high stage RCC.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
55
Issue
1-2
Start Page
106
End Page
111
Sort Key
106
Published Date
2008-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences